William Henry Harrison was born into an influential political family on February 9, 1773 in Charles City County, Virginia. Harrison's father was a wealthy Virginia planter who signed the Declaration of Independence and later became governor of Virginia.

Harrison attended Hampton-sydney College and studied classics and history. He next moved to Richmond to study medicine. In 1791, after the death of his father, Harrison stopped studying medicine and joined the U.S. Army. He was sent to the Northwest Territory (present day Ohio, Indiana and Illinois), where he served as an aide to "Mad Anthony" Wayne. Under Wayne, Harrison learned how to command an army of frontier soldiers.

In 1798, Harrison resigned from the U.S. Army and became Secretary of the Northwest Territory. In 1799, Harrison was elected as a delegate representing the Northwest Territory in Congress. After helping to gain passage of the Harrison Land Act, which made it easier for settlers to buy land in the Northwest Territory, Harrison resigned as a delegate from Congress and became governor of the Northwest Territory. As governor, Harrison secured a vast expanse of land at the expense of the Indians who inhabited it. Indian resistance, under the leadership of Tecumseh and Tenskwatawa, would soon become violent. In 1811, Harrison and 1,000 soldiers marched to Prophetstown, Indiana (an Indian village) for the purposes of removing the Indians. An epic battle ensued, known as the Battle of Tippecanoe, in which Harrison and his men massacred the Indians. Later, in the War of 1812, Harrison commanded an army that routed the British at the Battle of Thames (in present day Ontario). Harrison instantly became a war hero.

After serving in both the Ohio Senate and House of Representatives, Harrison was elected to the U.S. Senate. He served in the Senate until he was appointed Minister to Colombia in 1828. In 1836, Harrison ran for president of the United States, but was defeated by Martin Van Buren. In 1840, Harrison again ran for president and was elected in a landslide victory. Harrison's vice president was John Tyler. Their catchy campaign slogan "Tippecanoe and Tyler too" is one of the most famous in American history.

Harrison took office on March 4, 1841. That day, Harrison delivered the longest inaugural speech in American history - in the bitter cold. Harrison quickly developed a cold which turned into pneumonia. Despite intensive medical treatment, Harrison died just one month later. He was the first president to die in office. To this day, his presidency was the shortest in American history - 32 days.